Corneliu Giurgea coined the term nootropics when this new class of molecule was discovered in the 1970s. They are central nervous system stimulants, and they are used to treat a variety of conditions which we will explain in more detail shortly. Also known as cognitive enhancers, or colloquially as 'smart drugs', they can increase concentration, motivation, memory, and alertness. There have been numerous clinical trials studying the efficacy and safety of various nootropic drugs for different conditions and they have been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK.
Many people choose to buy nootropics due to their high efficacy rating and safety profile. Even though many of the medications are a schedule IV controlled drug in the US, they have a POM (prescription only medication) status here in the UK and they are available with a prescription on the National Health Service (NHS). If you are unable to get a prescription however, you can buy nootropics in the UK from our online pharmacy. Additionally, Nootropic supplements can be bought over the counter (OTC), but as there are far fewer clinical trials associated and the ingredients are not regulated, the efficacy cannot be guaranteed.
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What are Nootropics Used For?
Nootropics have a range of uses as we mentioned earlier, including licenced and off-label uses. Off-label doesn't mean it can't be prescribed legally, and medications are commonly used for off-label uses. The most common use is to treat narcolepsy, which is a rare neurological disorder, not fully understood. It is thought to be caused by a lack of the neurotransmitter called orexin, also known as hypocretin, which regulates wakefulness. Orexin is an important part of the sleep-wake cycle and although people with narcolepsy have the same amount of sleep as the average person, they fall asleep without warning during the day with no apparent cause. Although there is no cure for the disorder, nootropic drugs can help manage the symptoms. They are also used to manage the symptoms of attention deficit hyperactivity disorder (ADHD); however, the mechanism of action is not fully understood. Despite the medication being a stimulant, it is thought that the cognitive enhancing properties help with inattentiveness. As we mentioned earlier, these types of medication are also used off-label. Some of the conditions that nootropics are used to treat include the following:
Chronic Fatigue Syndrome - this long-term condition involves a wide range of symptoms. Some of the more common ones are flares or attacks of the condition after conducting ordinary physical activities, great difficulty in accomplishing normal tasks, and issues with sleeping. The fatigue associated with this condition is not relieved by resting, so by taking medication like wakefulness promoting agents, it can help to alleviate the tiredness that is experienced, allowing someone to go about their normal life. It is estimated that between 250,000 to 1,250,000 people in the United Kingdom suffer from this condition. Additionally, around twice as many women suffer from it than men.
Fibromyalgia - this condition is characterized by chronic pain experienced all over the body, as well as tiredness, excessive daytime sleepiness, and neurocognitive disorders. The cause of this disorder is unknown, but scientists believe that it may originate from a combination of environmental and genetic factors. Although there is no universally accepted cure or treatment for this condition, it is accepted that the tiredness and excessive daytime sleepiness can be treated with nootropics.
Students also use nootropics for focus due to their cognitive enhancing properties during exam periods or when completing assignments. You can also get nootropic supplements for this purpose; however, they are not regulated medications so will not have to adhere to the same safety standards, and they may be marketed and labelled incorrectly. So, before you buy nootropics of any kind, make sure to do your research to ensure they are safe and legitimate.
Which are Synthetic Nootropics?
A lot of people search the term 'nootropics meaning' and there is a myriad of information out there, so we're going to give you the ins and outs of the different types. When thinking about the nootropic meaning and whether synthetic or natural versions are better, it really comes down to what you are using them for. Synthetic versions are considered by most to be the best nootropics due to their high efficacy rating and because they have undergone many clinical trials and they have been developed over many years. Synthetic essentially means synthesised, or man-made. This does not mean they are harsh chemicals or that they are unsafe. Quite the opposite in fact due to the safety protocols set out by the governing body of each country, which is the MHRA in the UK. And if you think about it, chemistry is the foundation of life itself - everything is made of chemicals. As they are stronger and more effective than their 'natural' counterparts, there is a slightly increased risk of side effects, but these are uncommon, and we will go into more detail about any risks associated with the medication shortly.
What are Natural Nootropics?
Natural nootropics are essentially plant-based versions of the synthetic medications. This means they are generally less strong, however this can be beneficial to some people, such as those who are sensitive to stronger medications. One downside to nootropic supplements is that they are not regulated by the MHRA or any other governing body, so private companies can market them how they wish, and a variety of strengths are available without any guidance as to which is most effective for your needs. Some examples include the following:
Caffeine - this is the most widely consumed naturally occurring psychoactive substance globally. It works by blocking certain receptors in the brain, called adenosine receptors, making you feel less tired.
Ginkgo biloba - this plant-based supplement is thought to increase short-term memory and concentration, while also reducing the levels of cortisol in the brain, which is a stress hormone. Studies researching the effects of these supplements, however, have had mixed outcomes and more trials need to be conducted.
L-Theanine - this is a naturally occurring amino acid found in green tea, or it can be bought as a supplement. It is thought to be most effective when combined with caffeine and has been shown to increase concentration.
Omega-3 Fatty Acids - these are some of the most well-known and considered the best nootropics that are naturally occurring by many. They are found in oily fish and again, can be bought as supplements. These are available to buy OTC in local shops all over the country.
Bacopa Monnieri - this is a herb which has been used for centuries to increase concentration and alertness. Some studies have found that in increases short-term memory as well as reaction times.
Rhodiola Rosea - this is a herb which can boost your mood and decrease anxiety. It also helps you to better cope with stress and eases fatigue.
How Do Nootropics Work?
A lot of people buy nootropics because they find them effective. But how exactly do they work? Although the exact mechanism of action is not fully understood, it is known that the medications are central nervous system stimulants. This means they boost the electrical activity in certain areas of the brain. Each type of medication will have a slightly different way of working, but all of the pharmaceutical grade medications will target the same receptors. Cells in the central nervous system are called neurons, and between each neuron in a tiny gap called a synapse, and it is here that most receptors are located. Information is transmitted via electrical signals along the neurons, and they are regulated by neurotransmitters. Neurotransmitters are chemicals which can either be inhibitory or excitatory. It is thought that the active ingredients are agonists for dopamine receptors, increasing the production of the neurotransmitter dopamine and also prevents its re-uptake into the neuron via the synapse. This means there is more dopamine in your system, which is a neurotransmitter associated with motivation, happiness, and alertness. The increased levels of dopamine also indirectly increase the levels of orexin which is associated with wakefulness as we mentioned earlier. This is particularly useful for those with narcolepsy and for students who need to stay awake and alert. As we mentioned before, natural nootropics are not regulated by the MHRA and so the mechanism of action for the various types cannot be fully explained within the scope of this article.
Nootropic Dosage Guide
There will be different dosage instructions for different nootropics, and the amount and schedule will depend on the type and severity of the condition being treated, including whether it is chronic or acute. If you are taking Ritalin for example, you would usually be started on 5 mg to 10 mg split into 2 or 3 doses per day, up to a maximum of 100 mg daily. Adderall can be taken every 4 to 6 hours, and the dose is usually started at 10 mg, up to a maximum daily dose of 60 mg. Modafinil is usually started at 200 mg, with 1 or 2 doses per day depending on the condition. The maximum amount of Modafinil that can be taken daily is 400 mg. It is important to space the doses evenly throughout the day if you are taking more than one dose to prevent too much building up in your system at once. Tablets should also be swallowed whole, because if they are chewed or crushed in any way, this again can cause too much to enter your system at once, which can be dangerous. A popular slightly stronger substitute for modafinil is Armodafinil.
Nootropics Side Effects
Like every medication, nootropics have the potential to cause side effects. Most people do not experience any and for those that do they are usually mild and clear up on their own after a few days. Different medications will have different side effects, but some of the more common nootropic side effects include the following:
It is very rare, but before you buy nootropics online you should be aware that some people experience more serious side effects. If any of the following affect you, you should stop taking the medication and seek medical advice:
Angina or chest pain
Hallucinations or delusions
Do Nootropics work?
There have been numerous clinical trials studying the efficacy of pharmaceutical grade nootropics such as Modafinil UK and they have shown to be highly effective for management of neurological conditions such as narcolepsy and ADHD. Although clinical trials studying memory and concentration have mixed results, anecdotal evidence from students have shown that they benefit from nootropics for focus during exam times and when they have a presentation or assignment due.
Before Buying Nootropics
Before you buy nootropics online make sure that you have done your research and know that this is the best type of medication for you. You may want to try natural supplements before taking pharmaceutical grade medications. Additionally, you should avoid taking nootropics if any of the following apply to you:
You have a psychotic disorder
You have been treated for addiction in the past
You are taking other stimulant medication
You have heart problems
You are pregnant or breastfeeding
This list is not exhaustive and if you are worried about taking any medication you should seek advice from your GP.
Where to Buy Nootropics
You can ask your GP for a prescription as medications such as armodafinil UK are available on the NHS. We understand that this is not possible for everyone due to a range of factors including lack of time or even embarrassment about seeking help. We believe that if you have found a medication that works for you then you should be able to get it. That is why we have made it possible to buy nootropics in the UK without the need for a prescription from our online pharmacy. Our products are affordable, and we ensure that each order is shipped quickly and in plain packaging for discretion. Visit www.ukmodafinil.com for our full range of products.
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